Bio Platform Companies  
     
 
    Challenges
 
     
 

Biotech Platform companies innovate and produce the high throughput ‘Discovery Engines’ of the Industry which enable complex and large scale experiments like in silico prototyping, Pathway Mapping, Gene Expression Profiling, Genotyping  and Molecular Diagnostics.

The key challenges that this segment faces are:

  • The need to offer customers validated and relevant content along with their platforms to ensure better acceptance and usage. Customers demand a host of assays and data for various research applications including disease specific content, stem cell genomics, pharmacogenomics and toxicology.
  • The need to offer computing support to enable the analysis of the Giga and Terabytes of data that their high-throughput platforms churn out.
  • The need to enable their customers to use and manage their equipment optimally through user friendly software.
  
 
    Solutions
 
     
 
  • Assay Development:

    Polyclone offers Assay Development for disease and application specific panels and content for a variety of in silico/ HT Platforms in:

    • Cancer
    • Workflow
    • Infectious Diseases
    • Toxicology
    • Pharmacogenomics

Breast Cancer Assay Development Workflow (will be included)
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  • Comparative Studies:

    Polyclone has access to a wide range of technologies in-house and through partnerships, and can perform comparative studies across a range of industry leading platforms in

    • Microarrays
    • qPCR
    • Genotyping
    • Gene Expression Profiling
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  • Contract Research and Data Analysis

    Polyclone offers exploratory research and investigative services on a contractual model. These contract services enable customers to decrease time and costs to market by leveraging Polyclone’s expertise in research and development, bioprocess scale-up, pilot scale manufacturing, technology and economic assessments. Areas of expertise include:

    • Chemical Reagents
    • Recombinant DNA Services
    • Specialty Oligonucleotides design and analysis
    • Cell based Transfection/assays.
    • Assay development for screening
    • Qualitative/quantitative assays for detection
    • Viral load testing
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  • Management of High Volume Data

    • Management: Polyclone‘s software consulting team offers services to effectively manage giga and tera bytes of data generated from several sources and applications:

    • High volume data management
    • Data integration
    • Application parallelizing services
 
   
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  • Statistical Analysis

    A large part of data that is generated in high volume tends to be unused or disjoint. This not only hides the important information that is needed, but slows down decision-making and fails the very purpose of the high throughput experiment.

    Polyclone offers Statistical analysis and visualization services combined with scientific inputs that ensure the conversion of High Volume data into Meaningful, Decision Enabling Biological knowledge.

    Using a mix of Statistical & High Volume Data Processing techniques and genomic insights, Polyclone offers:

    • Numerical Analysis, Statistical and Graphical analysis for  Computing values of functions
    • Interpolation, extrapolation and regression analysis
    • Solving equations and systems of equations
    • Solving eigen value or singular value problems
    • Optimization through various algorithms including
    • Artificial neural networks
    • Hierarchical clustering
    • Dendograms and Heatmaps

  
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  • Bioinformatics Tools and Services

    • Nucleic Acid Design and Analysis:

      Polyclone offers comprehensive Nucleic acid design and analysis 6services for Microarray and PCR requirements for various applications including SNPs, Gene Expression Studies, CGH, Chip-on-Chip and Pathogen Detection.
      Using a combination of industry recommended as well as proprietary algorithms and neural network techniques, Polyclone provides stringent oligo design followed with in-depth Microarray/ qPCR data analysis services. Algorithms have been developed for the design and analysis of:

      • Probes
      • Primers
      • Taqman
      • Molecular Beacons
      • Scorpions
      • Lightcycler
      • siRNA
      • miRNA
      • LNA

    These can either be offered as a service or a web-based/ off-line tool can be developed.
 
Click here to learn how we designed a long-oligo based array for a bacterial genome for a German Microarray Technology company
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    • Custom Application Development and Maintenance:

      Polyclone’s software consulting team offers custom application development and maintenance services for various requirements. Some examples:

      • Experiment Design and Reporting: Bioinformatics Applications that are embedded with the Platform to help end-customers in using them optimally, designing the experiment and analyzing the resultant data.
Click here to learn how we developed an application for qPCR primer design for a Germany High Throughput equipment developer
   
      • Automated Ordering: Integration of instrumentation with order-placement system to automate ordering from the suppliers, in a ‘just in time’ and flexible manner
Click here to learn how we integrated an automated oligo ordering system in a PCR based assay validation process
   
      • Custom Genomic and Proteomic Alogrithms : -   Design of Custom Algorithms for specific genomic and proteomic problems
Click here to learn how our consultants developed an application for capture sequences and probes for the input genomic or CDS sequences
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  Assay Development  
  Comparative Studies  
  Contract Research and Data Analysis  
  Management of High Volume Data  
  Statistical Analysis  
  Bioinformatics Tools and Services  
   
Nucleic Acid Design and Analysis
Custom Application Development and Maintenance
 
       
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